Main Scientific Areas of Expertise
- Molecular imaging
- Prodrugs design
- Organic, organometallic, organophosphorus compounds synthesis
A. Professional preparation:
BSc/MSc Chemistry
Higher Chemical College, Russian Academy of Sciences, D.Mendeleev University of Chemical technology of Russia, Moscow, Russia (2003-2008)
Courses: General and Physical Chemistry, Theoretical Inorganic Chemistry, Chemistry of Elements, Inorganic Chemistry (Lab), Theoretical Physics (Classical Mechanics, Electrodynamics, Quantum Mechanics), Mathematical Analysis, Linear Algebra, Problems of Sustainable Development, Graph Theory, History and Philosophy of Science, Computer Science, Analytical Chemistry, Analytical Chemistry (Lab), Theory of Probability and Mathematical Statistics, World history, Crystal and Structural Chemistry, Organic Chemistry, Organic Chemistry (Lab), Physical Chemistry, Quantum Chemistry, Quantum Chemistry (Lab), Structure of Molecules, Calculus of Approximations, Physical Methods in Chemistry, Machine Search of Information, Chemical Kinetics, Sociology, Polymer Chemistry and Physics, Catalysis, General Chemical Technologies, Economics, Group Theory, OS UNIX, Advanced Organic Synthesis, Organometalic Chemistry, Nuclear Magnetic Resonance, Chemistry of Heterocyclic Compounds, Bioinorganic chemistry, Metal complex catalysis.
PhD School
A.N. Nesmeyanov Institute of Organoelement Compounds, Russia Academy of Sciences, Moscow, Russia (2008- 2011)
B. Work experience:
Research Area
Place of Work
Chief
2004 – 2006
Synthesis of N4-modified nucleosides with potential antiviral activity.
Laboratory of Molecular Biology, V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
Dr Lyudmila A. Aleksandrova, PhD
2006 – 2008
Synthesis and properties of merocyanine dyes in the range of thiophene derivatives
Laboratory of Heterocyclic Compounds, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
Dr. Valerii Z. Shirinyan
2008 – 2011
Synthesis, characterization and structure–activity relationship of novel N-phosphorylated E,E-3,5- bis(arylidene)piperid-4-ones
Laboratory of OrganothiophophorusCompounds, N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow
Prof., Dr. Irina L. Odinets
02.2010 – 08.2012
Theoretical study of structure and spectroscopic properties of materials for photodynamic therapy
Department of Chemistry, New Mexico Highlands University, Las Vegas, NM 87701
Dr. Tatiana Timofeeva
C. Publications:
1. V. Makarov, E.S. Leonova, E.Yu. Rybalkina, P. Tongwa, V.N. Khrustalev, T.V. Timofeeva, I.L. Odinet, “Synthesis, characterization and structure–activity relationship of novel N-phosphorylated E,E-3,5-bis(thienylidene)piperid-4-ones”, Eur. J. Med. Chem., 45, 2010, 992-1000.
2. E.S. Leonova, M.V. Makarov, E.Yu. Rybalkina, Sh.L. Nayani, P. Tongwa, A. Fonari, T.V. Timofeeva, I.L. Odinets,” Structureecytotoxicity relationship in a series of N-phosphorus substituted E,E-3,5-bis(3-pyridinylmethylene)-and E,E-3,5-bis(4-pyridinylmethylene)piperid-4-ones”, Eur. J. Med. Chem., 45, 2010, 5926-5934.
3. E. Leonova, M. Makarov, Z. Klemenkova, I. Odinets, ” Lewis acids as mild and effective catalysts for the synthesis of 3,5-bis[(hetero)arylidene]-4-piperidones”, Helv. Chem. Acta, 93, 2010, 1990.
4. V. Makarov, E.S. Leonova, E.Yu. Rybalkina, G.-V. Röschenthaler, T. V. Timofeeva, I. L. Odinets., ”Synthetic approaches to cytotoxic amidophosphates, aminophosphonates and aminobisphosphonates with 3,5-bis(arylidene)piperid-4-one framework”, Phosphorus, Sulfur, and Silicon, 186, 2011, 908–917.
5. A. Fonari, E. Leonova, M. Makarov, I. Bushmarinov, I. Odinets, M. Fonaria, M. Antipin,T. Timofeeva, “Experimental and theoretical structural study of (3E,5E)-3,5-bis-(benzylidene)-4-oxopiperidinium mono- and (3E,5E)-3,5-bis-(4-N,N-dialkylammonio) benzylidene)-4-oxopiperidinium trications”, J. Mol. Struct., 2011, 1001, 1-3, 68-77.
6. A. Fonari, E. Leonova, M. Antipin, “On justification of Cu(II) environment in mononuclear complexes: Joint X-ray and AIM studies”, Polyhed., 30, 2011, 1710–1717.
7. M.V Makarov, E.S. Leonova, E.Yu Rybalkina, V.N. Khrustalev, N.E. Shepel, G.V. Röschenthaler, T.V. Timofeeva, I.L. Odinets, “Methylenebisphosphonates with Dienone Pharmacophore: Synthesis, Structure, Antitumor and Fluorescent Properties”, Archiv der Pharmazie, 01/2012; DOI: 10.1002/ardp.201100352.
8. V.Z. Shirinian, A.A. Shimkin, A.K. Mailyan, E.S. Leonova, M.M. Krayushkin, “Convenient Synthesis of Diarylpropargyl Alcohols”, Mend. Commun., 2011, 339-340.
9. E.S. Leonova, N.S. Makarov, A. Fonari, R. Lucero, J.W. Perry, D.M. Sammeth, T. Timofeeva, “Synthesis, structure, one- and two-photon absorption properties of N-substituted 3,5-bisarylidenepropenpiperidin-4-ones”, J. Molec.Struct., vol. 1037, 2013, 288-293.
10. V.N. Khrustalev, Sh.L. Nayani, E.S. Leonova, L.N. Puntus, D.M. Summeth, M.V. Makarov, I.L. Odinets, T.V. Timofeeva, “Structure–property relationships for N-phosphoryl substituted E,E-3,5-bis(arylidene)piperid-4-ones”, J. Mol. Struct., vol. 1043, 2013, 68–74.
11. M.V. Makarov, E.S. Leonova, E.Yu. Rybalkina, T.V. Timofeeva, I.L. Odinets, New fluoescence cytostatics from the range of phosphorcontaining 3,5- bis(arylidene)-4-piperidones //Scientific Conference BIOLOGICALLY ACTIVE SUBSTANCES: Fundamental and Applied Problems, Novy Svet, AR Crimea, Ukraine, May 25–30, 2009, 121
12. E.S. Leonova, M.V.Makarov, T.V. Timofeeva, I.L.Odinets, Application of Lewis acids and bases for the synthesis of 3,5-bis[(hetero)arylidene]-4-piperidones.// International Conference chemistry of nitrogen containing heterocycles., Kharkiv, Ukraine, 2009, P-93.
13. M.V. Makarov, E.S. Leonova, E.Yu. Rybalkina, T.V. Timofeeva, I.L. Odinets, Synthetic Approaches to Cytotoxic Amidophosphates, Aminophosphonates and Aminobisphosphonates with 3,5-Bis(arylidene)pirerid-4-one// 18th International Conference on Phosphorus Chemistry., Wroclaw, Poland, July 11-15th, 2010.